Effect of short term treatment with captopril on IV bolus digoxin kinetics in dogs

The effect of a short-term treatment with captopril on IV bolus digoxin kinetics has been investigated in 6 normal dogs. A dose of 0.05 mg/kg digoxin was given to each dog and blood samples were collected for digoxin assay. The dogs were then given captopril [20 mg/kg orally] for 10 days followed by a similar IV bolus dose of digoxin and blood samples were also collected for digoxin assay. The results showed that serum digoxin concentration-time curve declined biphasically in the first 24 hours after administration. The Cp max significantly decreased by 39%, while the t max was prolonged by 64%. The distribution of digoxin in the central compartment [t/1/2 alpha and Vc] was not statistically different under the effect of Captopril while the elimination phase half life [T/1/2 alpha and beta] was longer by 106% and the apparent volume of distribution [Vd] was increased by 85%. The area under the curve [AUC] was increased by 17%. These changes indicated that Captopril can reduce digoxin elimination as shown by the reduction in digoxin clearance and the increase in the AUC

Nuevos conceptos en el tratamiento de la fibrilación auricular / New concepts in the treatment of atrial fibrillation

La fibrilación auricular (FA) constituye un problema de salud pública por su alta frecuencia, y por los riesgos que conlleva. En este trabajo se hace la revisión actualizada de las drogas que se pueden utilizar en sus tratamientos haciendo énfasis en los pro y contras de las mismas. Además se revisan aspectos relacionados con la cardioversión y sus complicaciones. Se establecen los riesgos del accidente cerebrovascular (ACV) dependiendo de la génesis de la FA y se examinan los posibles efectos benéficos de la terapia antiagregante